Showing posts with label memory. Show all posts
Showing posts with label memory. Show all posts

Wednesday, May 13, 2009

The Long Journey

I've written a lot about my health over the past few years, and my efforts to try and do something about it. Each little clue gave me new hope, into which I threw my full energy. I took every inch and reveled in it, moving as far as I could before inevitably declining once again (increased effort met with increased resistance). These were genuine steps forward though, rather than false starts: I lost weight, gained focus, and started sleeping better, so each time I was really complaining from a new place.

The biggest gains came from discovering sleep apnea, candidiasis, and suspicions of mitochondrial myopathy. None of these are naturally indicative of McArdle's Disease (the eventual diagnosis) though, nor are they typically concomitant. They didn't fall into their place in the puzzle until the picture was already becoming clear, when it all suddenly came together.

I should start by explaining a little about the condition. Glucose is the primary source of energy for nearly everything in the human body, the whole process referred to as "glycolysis." Most cells, especially muscle cells, have an internal reserve of it in a compact polymer-like form called glycogen. When demand for energy increases, molecules are trimmed off the end of the chain and made available to the mitochondria to do their business of converting it into active energy (adenosine triphosphate, for those taking notes).

This store of energy is pretty high - enough for 12-20 hours worth of activity before needing to be replenished. That replenishment happens on a regular, ongoing basis, to keep stores topped off whenever spare glucose is available, and any surplus is either excreted or converted into starches and stashed elsewhere. Normally this is enough to keep the body readily burning glucose between meals without running low - an exception would be fasting (more than a day), starvation, or extremely high demand: marathon runners, for example, can completely deplete glycogen stores after about 20 miles of continuous running, a phenomenon they refer to as "hitting the wall." At that point continued activity requires use of the stored fats as an alternative fuel, and risks damage to those tissues unable to do so.

McArdle's refers to a defect in or absence of myophosphorylase, which is a fancy name for "the enzyme that breaks glucose off the glycogen chain." This deficiency means that the primary source of stored energy is either completely off limits or so impaired as to be unable to meet the body's demand. This results in dramatic exercise intolerance, and in some cases cramping or seizing of muscle fibers (which require energy both to contract and relax) in a disparate and uncoordinated state so severe that they can actually rupture (rhabdomyolysis - this will be on the test), spilling their proteins into the blood and straining renal functions. Alternatively, the secondary fuel source based on fatty acids can be engaged (lipolysis).

An interesting side note here is that this is the primary intent of low-carb diets: by lowering the intake of glucose (and things easily synthesized into it by the metabolism), glycogen stores are exhausted and the body has no choice but to turn to lipids in order to remain functional. It's a hack, but a potentially effective one - your mileage may vary though, and not every system can handle the kind of stress this creates.

To point, too heavy a reliance on lipolysis floods the body with its waste products and increases the acidity of the blood (ketoacidosis). Healthy folks don't normally get to this point - diabetics can be affected in pretty nasty ways though. Those with McArdle's suffer a similar fate since the reliance on it is more absolute, and constant: this happens on regular diets without regard for carbohydrate intake. I had hit on a form of metabolic acidosis in my investigation earlier but had come to it from the wrong side, thinking that it was an inhibition of the mitochondria in making use of available oxygen, when in fact the mitochondria work wonderfully and are simply making-do with limited materials on hand. The effect is the same though: fatigue, memory disruption, stupor, and eventual unconsciousness.

I hit on McArdle's as a possibility in my own studies just before I was recruited by Amazon, though there were a couple of things that didn't quite add up for me. The subjective descriptions of other sufferers sounded really really close, a better overlap for my experiences than anything else I'd encountered to that point. However, I didn't have the severe cramping, nor the myoglobinuria - the voiding of protein from the damaged muscle in such a way as to turn urine red or "rust colored." I grew up in the Pacific Northwest: rust, in that high-humidity environment, is a bright orange or red. I'd experienced darkened urine before (sorry to get visceral here), but it was more brown than anything else, was very infrequent, and not repeatable under controlled conditions. During a physical before relocating to Seattle I asked them to run a CPK, which looks for serum creatine kinase (the chemical marker of that damaged muscle) which is elevated in 90% of McArdle's sufferers: results came back normal and I scratched this one off the list.

Once in Seattle, apart from the family, I decided to give myself a break in some respects. Since I didn't have anything better to do (no family, trying to save money since I was living separately, and not particularly interesting) all I really did was work and sleep. I allowed myself to sleep whenever I wanted to, extended naps after work, sleeping-in on the weekends with a nap or two on Saturday and Sunday (each!), until eventually waking up from a nap didn't hurt - I didn't shudder or feel sick within a few seconds after starting to move, and then something even more surprising happened: I stopped needing the CPAP at night. The sleep apnea completely vanished for a time, as long as I was napping with such high frequency.

The results were amazing. I slept better, dreamt more frequently, and was even able to take longer walks. I lost about 10 pounds in a couple of months without changing my diet (I mean come on, I was eating like a bachelor - a bachelor who can cook, granted, but not especially health conscious and with a penchant toward mint ice cream in the evenings). After those couple of months the work schedule started to pick up and my resting decreased, the CPAP came back on, and exercise tolerance reined back in to the "inhibited" range. The stress was a lot higher too - being apart from my family for several months had sucked all the fun out of exploring a novel place. I felt a need to demonstrate to the powers that be that I was not taking any of it for granted, and dove into the work with all the vigor I possessed to make the most of the fortune bestowed upon me: man, did I ever work hard, even during the once-monthly weekend visit back to see my wife and daughters. We did everything we could to help sell the house make judicious use of our resources.

After three months my corporate housing benefit expired and I was forced to find a new apartment on my own dime. I narrowed it to a pair of places relatively close to work and made the move. Interestingly enough, one of the two could never correctly coordinate a showing: three different attempts always saw the super pulled away on some other issue or ill, and I was forced to take the other without ever earnestly evaluating the competition. The reason this is an interesting fact is because the one I got was up the steeper hill, a crucial contribution to the eventual diagnosis.

I ramped up my work even more. During the holidays things are busy in the retail world, and Amazon doubly so (on account of being good at what they do). My areas of responsibility overlapped with physical operations, so everything was closely monitored and actively engaged. I would work 9-10 hours at the office, walk the 1.1 miles back up the hill to the apartment (or in a real pinch take a shuttle bus - I was living across the street from one of Amazon's facilities, just not the one I was supposed to work at, and they have shuttle service between them), have my video chat with the family before the girls went to bed, and work another 6-8 hours on average. Saturdays I would put in only 4-5 hours, and try to rest on Sunday (except for the emergency processing which had to be attended to at 10 pm daily, no exceptions, and any pages I received). It shut me down: I suffered through it because I had to, but the limited treatment I had for the sleep apnea became ineffective and the afternoon meeting narcolepsy started creeping back up on me.

Clearly, this was unacceptable. I was trying to completely own the job and attendant performance expectations out of a desperate display of over-compensation for any perception of my own failings, and still demonstrate to the cosmos that the blessing of opportunity had not been misplaced. I would magnify what I'd been given, and failure was not an option: I re-opened an investigation into my health, starting over with new physicians and determination to finally see it through and regain some dignity. I was also armed with the recommendation from my last consultation in Utah that I follow-up with a neuromuscular specialist to see if they could find anything.

I got myself a referral and an appointment a month in the future. Tired of repeating myself and feeling like I was leaving out anything of relevance, I typed up my medical history and current state of symptoms and controlled conditions under which they were manifest and went into the consult armed with a fairly exhaustive twelve page document. Having previously personally ruled out McArdle's, I essentially wrote around it: made no mention of mitochondrial disorders, glycogen storage issues, anything of the like. I actually gave it a bent slightly toward some kind of transient ischemic event: the intense walk back to the apartment after a series of grueling days eventually resulted in some pretty nasty aches, but not until I took a break and rested. It was only well after the exertion that muscles seized up, and then after a power nap turned into a deep and exhausting pain that easily brought me to tears. On a scale of 1-10, with 1 being pain free and 10 being unconscious, this rates a 7; for comparison, a root canal tops out at 4 and deep lacerations a 6 at most (it'll send me in to shock, but tears are a distant thought). I took this to be a potential sign of ischemia (inhibition of blood flow, usually localized) due to the fact that deep tissue damage from suppressed blood supply doesn't happen in full force until that flow is restored (re-perfusion injury and apoptosis). The resulting darkened excretion following 12-24 hours later confirmed some kind of muscle wasting, but again given its brown color I associated it more with necrotic tissue than a possibility of the more traditionally red myoglobin.

At the appointment, after a very brief evaluation to make sure there was nothing glaringly pathological, the specialist looked over the history and immediately recommended McArdle's as though it was already on the tip of his tongue. I told him why I'd ruled it out, specifically noting the negative CPK test, but by then he'd closed the folder and was wearing that medical professional look of, "I'll listen to you, but I'm pretty sure I already know what's up and am not likely to take it under real consideration." He made no additional notes, and simply stated that he'd like to see me again after my consult with the neurologist (to see if it really all was in my head - though legitimately based on neurological function, rather than psychosis per se).

The neuropsychiatric evaluation was set for the middle of May. Only, I could swear the receptionist told me a corresponding date in March. I showed up on that date with all my paperwork filled out, ready to go, and was a little chagrined to learn I'd rearranged my schedule for something not due to happen for another four weeks. They offered to add me to the waiting list in case something earlier came up, which I accepted, and went back to work dejected.

Prompted by the prior meeting and hint toward McArdle's from the neuromuscular specialist I did some more research, and found the available materials evolved somewhat since my prior glance in this direction. Someone equated "rust" with "brown," a real forehead slapping moment of course - not only was the event predictable enough that I should have seen it and been able to disregard the minor deviation, but I've seen brown rust long enough I should have adapted to a broader definition anyway. Secondly, an explanation that the cramping was not necessarily present in all conditions, and frequently occurs after the exertion or even during rest. Following as many threads as I could I tied the alternate lipolysis metabolism to non-diabetic ketoacidosis, which rounded out the remainder of my symptoms. I had a fit for everything, there was no part of my condition not explained by the disorder, and nothing in the disorder at odds with my presentation. I didn't know what to do about it yet, but after 15 years of intensely searching I received a concrete corroboration and vindication: life really was hard, and I wasn't simply incapable of handling otherwise normal levels of stress.

One week after that appointment, as I was preparing for my monthly trip down to see the family, I had my regular meeting with the boss to sync up. This time, however, rather than the one-on-one format, our friendly neighborhood HR representative was there. As nice as they usually are there are times you don't want to see them; this was, in fact, one of those times. Business concluded, boxes were packed, and with an hour to go before I was already scheduled to head out to the airport I found myself an unemployed victim of a tightening financial reality. The timing could have been better, certainly - relaying the news to my family under those circumstances was bittersweet. I was due to see them, and to return to be with them more permanently, but with an uncertain future. Not only that, but the steps I was taking toward possible management and resolution of my health were going to have to be put on hold once again: even with a continuation of health coverage through the next month and opportunity for COBRA it would simply cost too much, and without new work lined up I couldn't risk the family finances.

While I was down visiting the family and celebrating my daughter's birthday, I received a phone call: it was the neuromuscular department letting me know they'd had a cancellation and would I be interested in moving my appointment up from May 12th to the coming Monday? Talk about providence! My return flight was on Sunday night, and I was planning on immediately breaking down the apartment and closing off accounts so I could have my belongings packed up and be back on my way to Utah as an officially binding move (cats and all) by Thursday. If I were to be able to get this evaluation at all, that would be the only way and the only day to do it - I very gratefully accepted the rescheduling and continued to enjoy my time at home.

I returned to Washington and went in for the six hour battery of tests designed to exercise and measure the functional capacity of the brain. During a break in the tests I had the opportunity to speak with the prior specialist, from the earlier consult - I let him know my findings, and we chatted at some length about possible avenues for management (and how to begin exercising in a legitimately beneficial way despite the condition, rather than as a grueling ordeal of determination). The tests concluded with favorable results, I finished packing the apartment, and made the long haul drive (14 hours straight) to be home genuinely and officially: for the first time in seven months I didn't have a looming clock ticking away until my next departure.

Further study and experimentation has led me to the following series of conclusions and strategies:
  1. Most of the really nasty bits of McArdle's (the rhabdomyolysis, resulting myoglobinuria and possible renal failure) are only distantly present in my condition, which is certainly in my favor and gives me hope for decades to come.
  2. The majority of my symptoms are the result of persistent lipolysis and metabolic ketoacidosis, so things are working pretty well and happen to have unpleasant side effects.
  3. Minor snacking under ketoacidosis can in fact lead to a "sucrose induced second wind," but the body's already primed to store the excess since it's reacting as though starving (or otherwise resource impaired) and has slowly but constantly contributed to my weight gain over the years.
  4. A carbohydrate (especially sucrose) rich environment contributed to the candida albicans overgrowth of yore, long since controlled.
  5. Metabolic acidosis has a disproportionate effect on the diaphragm, even capable of inducing sleep apnea due to paralytic hypopnea (found some nice research papers on this).
  6. Acidic (low pH) blood is filtered by the kidneys, which neutralize it using bicarbonate.
  7. Most of the bicarbonate in the body is secreted by the acid pumps in the stomach, and an extra need for it does increase total pump output (acid reflux anyone?).
  8. THEREFORE: adequate rest, which prevents the accumulation of metabolic toxins and/or provides opportunities for their filtration, OR a heightened filtration schedule, should be able to restore a more normal functional baseline. In practice, this means I either have to take it really easy (intense aerobic activities of my youth are all off the radar) or find some way of flushing out the kidneys, which I can do by massively upping my intake of water.

The recommended daily hydration regimen is 8 cups (1/2 gallon, or 64 ounces). Most people don't quite get this (and to be fair, it is a pretty arbitrary standard), and feel a little water-logged if they go for it. I've found experimentally that my ideal water throughput for symptomatic management ranges from 1.2 to 2 gallons per day, or two to four times the standard recommendation. Putting upwards of ten pounds of water through my body a day is not without its inconveniences, but the results are astounding: I have been able to consistently function, retain focus throughout the day, and consistently move without a broad distribution of muscles slowly constricting and seizing (I ignored a lot of this before, it had settled in so gradually). In those cases where the toxicity increases beyond my ability to handle it with water I can supplement with bicarbonate (sodium-bicarbonate in this case, or common baking soda - unfortunately you can't get bicarb without it being bound to another agent, and sodium in the related concentrations is the least threatening) to give my kidneys a boost. If that's still not enough it's time to take it easy and sleep it off.

And that's it - I can do 2 miles on the treadmill in the morning and become warm and flush in the face, with a good steady and heavy sweat instead of my previous experience of becoming pale, pupils dilating, and pulse threatening to become erratic as I felt increasingly weak and physically disconnected. I'm invigorated and capable, and with any luck will be able to set a good precedent for weight management. I've been doing this for a month now and am still amazed at the clarity of thought, presence of mind, and restored function of an engaged subconscious (especially for automatic mental reminders and short-term background processing). There are things I'll clearly never be able to do again, but I'm more OK with that now than ever before - the burden is easier to carry, and I'm relieved of the expectation of rising to a super-human standard.

None of this would have been possible except for:
  1. Mental faculties adequate enough to both use as a means of trade in providing for self and family (and thus avoiding reliance on otherwise impossible physical performance), and sufficient to withstand the stupefying effects long enough to be effective in that employ.
  2. An opportunity to both rest and subsequently push myself in opposite extremes: without the intensity of work and schedule I never would have been able to consistently reproduce the final few symptoms of the puzzle. The new job, attempted relocation, and first and second apartments created the perfect environments.
  3. The urgency of investigation based on family need: I owed it to them not to screw things up, admitted I had a problem I couldn't solve on my own, and persisted in seeking out the care and advice I needed.
  4. The inability of our beautiful home to sell despite our efforts to undercut the market.
  5. That final appointment perfectly rescheduled (and only because I made a mistake that landed me on a waiting list) to coincide with my dramatically foreshortened stay in Washington. In fact, the foreshortening came on the heels of our most recent and drastic attempt to sell the house - almost as though we forced the hand of the cosmos, since we weren't really supposed to move but the evaluations still needed to happen.
  6. All the little steps over the years that gave me hope.

In the end it seems as though the whole experience with Amazon was perfectly designed for the investigation into and subsequent resolution of health that was continuing its frustrating decline (every minor gain was eventually curtailed). It was very costly: the time apart from family is not something I would otherwise have chosen. That's being quickly made up for though - before the severance ran out I managed to land a good gig locally, with a favorable commute, frequent opportunities to work remotely (time with the family and care for my health), a nice level of influence and corresponding title, and chances for some stability. Certainly more humble in many ways than the work at Amazon, but arguably far better suited for both me and the family.

I'm being taken care of; it feels like stepping from shadow into warm sunshine. Health is finitely understood and controlled for the first time in my life. I have a much better idea of relative costs now and know what I will and will not do at the expense of closeness to my family, and most of it falls into the "will not" category. I learned a tremendous amount (the kind of education you really can't pay for) and am better prepared for the advancement of my career than ever before; and I can start living again.

Thank you.

Thursday, March 22, 2007

Hypnosis and Trauma

The late Dr. Milton Erickson, a renowned psychiatrist and major innovator in terms of modern hypnotherapeutic theories and practices, once proposed that all learning is acquired in a form of trance. The conscious and unconscious minds align into a state of receptivity and thus of increased suggestibility, ready to accept the incoming information or experience as Fact and Truth. Thus, the sense of mental expansion felt during periods of intense focus while acquiring or applying knowledge, referred to commonly in pop culture as "the zone," is actually a type of waking hypnoidal trance. This theory is put into practice as an explanation for the efficacy of some encounters over others in forming lasting imprints, and to effectively address events within the memory by accessing the remembered trance state during which they were formed or reinforced. There are other, less deliberate conditions capable of inducing a similar selective focus, even contributing to hypersuggestibility (one of the goals of most hypnotic trance). Applications of extreme emotion, positive or negative, or adrenaline are especially effective.

Fear and trauma are a prime combination, snapping the mind into ultra-constricted awareness and attention to specific aspects of the given situation. Personal testimony provided by survivors of terrible events often include comments about how some small feature, perhaps even counter-intuitively and difficult to consciously reconcile after-the-fact, takes on increased significance disproportionate to other factors (try searching the web for "I just remember," quotes included). Beneath this conscious awareness, the sub-conscious performs similar singular attachment. The results of this extreme focus creates new triggers for the remembered trauma, and seemingly ordinary settings or items can reproduce the original emotional state and responses (one of the most disruptive conditions of flashbacks and Post-Traumatic Stress Disorder). The victim/subject of this experience will be unable to "let go" or become selectively unaware of the triggers, and the gut-wrenching realism of the recall causes enough distress as to interfere with daily living, as well as essentially reinforcing the response to the original stimuli in a self-perpetuating pattern.

Interestingly enough, the sub-conscious mind thinks it's doing a favor by initiating and exercising these connections.

One of the primary duties of the sub-conscious is protection of mental, physical, and emotional wellbeing. Its perceptions of what constitutes a threat do not necessarily agree with conscious opinion of the same, hence the seeming irrationality of many phobias and some behavioral disorders. Methods used for protection from the evaluated threat can similarly be at odds, capable of producing responses which one would not otherwise agree with. My old hypnotherapy mentor's materials included a case study of a woman in broadcasting who found herself suddenly unable to control her weight as she became more successful. All reasonable attempts at healthy diet and activity failed repeatedly, and the decline in her appearance began to interfere with that success (such is the business). Through therapy it came to light that years prior, during her communications schooling, she was informed by someone that she would "never get anywhere [in broadcasting] without sleeping with the right people." It was meant as a word of caution based on genuine concern and poor information, but stuck in her mind all the same. As she garnered attention for her efforts years later, her sub-conscious equated the impending success with the potential exploitation of her closely-guarded sexuality and formed a barrier to that negative expectation by lowering her appeal; all without conscious involvement or awareness.

Traumatic conditioning is much the same: a minor queue such as smell, the time of day or impressions of light and shadow, certain sounds, in addition to any overt similarities, can queue the sub-conscious to begin a protective response. Focus becomes selective once again and emotions and hormones run high, informing the conscious mind and primal instinct that fight or flight may be immediately necessary for self preservation. The similarity in physical and emotional reaction is so dramatically familiar as to force the recall of the original sensitizing event, bringing on the rehearsal of a deeply ingrained episode literally programmed into the mind.

Case in point, I recently had a minor weather-related accident in my car. The path of least destruction to others and property led me to a trajectory which damaged my driver's side C.V. axle and control arm, rendering the car undrivable and requiring extensive repair. I was not frightened or upset by the incident, though I did feel a little embarrassed for not judging the changing road conditions well enough and for the resulting financial setback. Once back behind the wheel, I found myself having moments of impending fear when decelerating for residential right turns: a startling, unbidden reflex out of sync with my (admittedly more cautious) thorough evaluation of the circumstances. It's taken me the better part of two months to unwire that reflex, and if not paying close enough attention or relaxing my efforts can still feel the sub-conscious intent.

No wonder then that severe, genuine trauma is capable of providing such long-lasting ill effects on the life and mental health of the sufferer. In an attempt to shelter a person from an anticipated real or imagined horror, it is possible for them to be adversely subjected to the same ill-affects they're trying to avoid. Due to the unintentional receptivity of the mind during the formation of the reflex, it's able to take root at surprising depth: easily enacted, difficult to remove. Common therapies attempting to soften the reaction through dissociative objective analysis (re-experiencing some elements in a safer environment, removing the reality of danger whilst maintaining triggers) can help, but may not ever be able to truly eradicate it. Could therapeutic hypnoanalytical techniques provide a better solution by addressing the triggers themselves?

I have not used hypnosis to remove my slight aversion to right turns, yet - I didn't think it disruptive enough to require such direct management. I also have not had opportunity to apply this to those suffering from any form of PTSD, though I'm intrigued by the potential. I'll have to give it a try on myself and report back.

Thursday, January 04, 2007

Full Brain Programming

A Geek's Take on Multi-Hemispheric Neurology and Software Development

The Brain

The human brain is separated into two distinct hemispheres, split down the middle front-to-back. Anyone familiar with basic biology will have seen this on cross section diagrams, as well as the generalized labels of specialization for the two halves. While it's true that the functions of higher consciousness within the neocortical regions of the respective hemispheres differ, it's also important to note the operative similarities and redundancy in the design as well.

Each half is equally paired to sensory stimuli as provided by taste, smell, sight, touch, and sound, as well as input from the limbic and primitive sub-areas of the brain which process and filter reactions to those stimuli before insertion into consciousness. The redundancy is not perfect, however, in that the signals received are those generated by a fixed half of the body directly wired into the respective hemisphere. The simultaneity of the combined experiences prevent this from being a disorienting experience however (since anything we hear with one ear is generally heard with both, for example) and is reassembled into a single contiguous phenomenon, leveraging hemispheric disparities to be able to proved depth perception and rudimentary echolocation, etc.

The real divergence comes when one reaches the frontal lobes. These portions are responsible for housing operations dealing with conscious thought and complex reasoning, doing so with a high degree of specialization. The right tends more toward the spatial, intuitive, abstract, emotional and creative tasks, while the left provides language, critical and logical thought, and temporal referentiality (chronological awareness). These are not separations of "personalities" inherently conflicted with one another, nor a contest of dominance within which there is any "proper" way to think or behave. Personality is a construct expressed across both sets of functions, and what matters to the personality matters equally within them, in their own ways.

Hemispheric (Un)Cooperation

But they don't communicate very well with each other. Which is not to say that there is an inhibition or implicit miscommunication which will confound information as it crosses between the the two. There is also, to borrow hardware design terminology, no latency or bandwidth restrictions on the communications bus. This bus takes the form of the corpus callosum, a dense bundle of nervous (meaning "of nerves," not "anxious or excitable") fibers whose only duty is to provide a channel by which information and data may be exchanged.

The difficulty in exchanging that data is based on differing APIs: the right hemisphere has no mechanism to appreciate the number 5, although it can be familiar with the shape and sound of it, and spatial groupings which miraculously come to the same total when counted. Similarly, the left hemisphere cannot comprehend the color yellow other than as a word (non-pictorially), wavelength of light, or hexadecimal RGB representation (my favorite tends a little more toward the golden variety with a touch more red/less green, an #FFED00). How then is it possible for a word to evoke spacial concepts, or for creative concepts to be placed within the logical structures required by software development?

It's interesting to note here that complex structures are almost always based on abstract spatial relationships rather than strict logic, and it is the rigidity of rules in the medium in which they are represented which forces them to appear complex. Most accountants are left-handed, showing a clear preference for the abstract processing capabilities of the right hemisphere - meaning they're also cut from the more emotional and creative fabric of society, directly opposite of the bean-counter exactitude embodied by the more simple and stereotypical book-keep the word "accountant" usually invokes. Real rules of accounting are difficult for us right-hander folk to grasp at a glance because we make the mistake of attempting to process them solely in within the logical realm of the left hemisphere, rather than correctly mapping them into their true spatial connotations on the right.

How does one establish this ability to do that translation if the two halves don't speak the same neurological language?

Memory & Concurrency

The first way is through the parallelism of experience, mentioned briefly earlier, and then through concurrency of processing.

Memory is stored across the entire brain as coordinated by the hippocampus (found in the limbic system atop the brain stem). Even though there are very different types of memory we'll treat them under the generic class name here just to be easier on the science. An event/experience or concept is stored in the brain the same way it is initially represented, as a series of impulses in a variety of locations. The memory is committed to long term storage as this impulse pattern is reinforced by branching of the synapses, which is literal physical growth and extrusion on the dendrites of neurons. The formation or reinforcement of the connections created by this growth make it more probable that subsequent stimulation in similar areas will reproduce a similar pattern or portion thereof, like the path-of-least-resistance in any electrical circuit. Trigger cells, regular neurons which just happen to fill this particular role during the memory formation, are then specifically assigned to be the gateway to the reproduction of the pattern in its entirety. The number and strength of the connections to the trigger help determine the likelihood and ease with which it can be remembered. Thus all habit and practice in the brain changes its shape, and does consume massive amounts of resources from the bloodstream; it's OK to be tired if all you've done all day is think really hard.

Since the experience takes place in both hemispheres simultaneously, there is a temporal coordination: a time-index which can be used to reproduce coinciding patterns. Returning to the example of color, a child knows what ____ is long before it knows what "yellow" is. Putting the two together is a matter of hearing the word at the same time the color is physically present, in enough different contexts (different objects of the same color, different textures and materials, smells, etc.) that the color stands out as the sole common right-brain event which overlaps with all of the times the funny-looking big person has been making the same new sound with their face. Once this gels and is well practiced, remembering and interacting with the stored fact in a variety of partial contexts becomes easier because the whole pattern is subconsciously reiterated. Largely through the acquisition of language, the process of learning simultaneously with both halves of the brain becomes a simple habit.

Once enough patterns are stored in this fashion, dwelling on their recall while exploring new territory creates the opportunities for the synthesis of new associations based on the discoveries of either hemisphere, still effective across the whole because they've coincided temporally once again.

The Full Brain

How then to use this to the advantage of a software developer or any discipline requiring interaction with highly-complex systems? Making the most of the specialization of both halves must be done by engaging each of them fully in the task at hand through the channels in which they are most apt.

For me, I'm barely able to function when I crack open a new API regardless of whether or not I'm already familiar with the language. The features and structures required by the unfamiliar interfaces have to be walked through, step by step, module by module until I can grasp them categorically and generically. Even then it takes a fair amount of practice within that framework before it becomes comfortable and intuitive, which it manages to do all at once with enough of the right kind of exposure: it just clicks. It is then that an analog for the logical structures has been created, and I can leverage the spatial navigational strengths of the right hemisphere to make my way around the program seemingly blindfolded.

The spatial mapping happens piece by piece, understanding the code as its general "physical shape" (patterns of line lengths or syntax highlighting), its relative position within its containing file (amount of code above vs. below), and more nebulously it's "flavor." This is an intentional synaesthetic translation of logic into kinds of phantom sensations: how the code makes me feel regarding its elegance and efficiency, the degree to which it needs to reach out to other modules vs. self-containment/sufficiency, etc. These become aspects of spatiality, but not something that can be drawn well or represented in three-dimensions because it is abstract enough to be not so constrained. The process may sound exotic, but happens largely unconsciously, and most developers do it to some degree or another.

Once a portion is in place, others then build off of it by using it as a point of reference, and soon the entirety of the application has a feel to it as well as a virtual expansive layout. The whole of this "abstractification" is like defining a subroutine - a simple function which stands in for a body of logic and can be comprehended simply by identifying the name of that function in the future. This allows for a higher-level overview, essentially zooming out on the granularity of the code all the way to an architectural flow diagram. It's the reason those things are ever drawn in the first place, and these methods of whole-brain analysis are the key for reverse engineering or developing the visual/logical relationships which result in a usable, maintainable product without overloading the mind. Which means, for you non programmers out there, we have some secret tricks we do to make all the gobbledygook into something meaningful; participation in this field is not an automatic indicator of intelligence or even aptitude (just take a look over at TheDailyWTF, which celebrates "Curious Perversions in Information Technology").

The conclusion? Try bringing the unconscious analysis to the foreground and more intentionally leverage the kinesthetic aptitudes. There are several ways of doing this and even artificially jump-starting it (diagramming with a non-dominant hand, for instance). Perhaps in a future article I'll explore exercises and tests designed around that, but for now this should be enough food for thought to expand your universe just a little more. And if not, it was a free read.