Sunday, February 11, 2007

Week II, Update

OK, I did get the stomach flu last night, but darned if I'm going to let it last long. And minus a few inconvenient interruptions, I still feel better than many of the days before starting the experiment.

Saturday, February 10, 2007

Now Leaving Week II

I've been trying something new for nearly two weeks now, specific to the management of my long-term cellular metabolic disorder. 2 weeks ago yesterday I was on the phone with my old buddy Dan in Washington, updating him on recent events and findings (Dan is doing well by the way, having given his notice at Clipper so he can apprentice full time under Rod Chappel). Some of the particular secondary symptoms sounded familiar to him, so he took a look through a homeopathic reference he had on hand and came up with: candida (apparently pronounced similar to "Canada").

In homeopathic circles, this normally helpful strain of yeast (present in the healthy colon, and responsible for keeping incoming pathogens at bay) is commonly blamed for a whole host of primarily gastrointestinal symptoms. On the web (scoured via Google, as always) it's fingered by nut jobs for just about everything the human body can suffer, usually accompanied by rants against "the establishment" and even calling for a boycott on the immunization of children. There is, however, some valid medical information to be found amidst the stream, referenced here from our good friend Wikipeda:
"Colonization of the gastrointestinal tract by C. albicans may result from taking antiacids[sic] or antihyperacidity drugs. This colonization may interfere with absorption of Coenzyme Q10.[3]"
That last bit really caught my eye. From having read up on the various causes and manifestations of sub-sets of mitochondrial myopathies I recognized the enzyme as one (out of five) critical for the aerobic respiration facilitated by mitochondria, the deficiency of which can cause the onset of the malady. The gastrointestinal upset associated also coincided well with the acid reflux (and other conditions) I've experienced and thought to be ancillary. Taken as evidence together with the indicators for the mitochondrial issue, I thought this just might be a smoking gun worthy of further investigation and started looking up treatment options.

Most of the ones published and referenced sufficiently to appear well in rankings are associated with said whackos, advocating intensive homeopathy and massive lifestyle changes for the sake of "personal balance." Now, I'm used to alernative medicines - I grew up near Seattle and there are quite a lot of them in the local culture (and the culture which gravitates there wanting to appear local). As a practitioner of martial arts I am aware of the flow of ki (or chi, depending on the country of origin for your discipline) and have been participant in and witness to events and activities which I have not been able to rationally attribute to anything else. However, I fall well short of believing that these things can be used to master the universe around oneself in dominant fashion - in fact, it is only through the utmost stillness and focus of mind and body that an awareness of the subtleties of flowing energy can be detected. Extrapolating from that into its potential influences on the physical world, there just isn't enough force to make a truly tangible or impactful difference. Thermodynamics and Newtonian laws simply tend to outweigh the whims of thought.

This calls for the introduction of an additional agent in order to affect change. Most candida specific treatments have glowing, amazing, miraculous testimonials attached to them, right before you reach the, "and now you can feel the same way with this astounding (and large, complex) regimen of supplements starting at only $64.99 a month!" The dominant products come from Japan, where the condition has been recognized and studied in greater detail and with more scientific acceptance, supposedly. I may be willing to give things a try, but I wasn't expecting to have to shell out for slick packaging around something which sounded suspiciously like snake oil; they sounded nice and official, explained well the effects they were addressing, but not from a position of pathology (didn't say how the symptoms and causes were connected), nor did they disclose the mechanisms by which they purportedly acted to adjust conditions: only that they restored a natural balance of intestinal flora. What really turned me off was the add-ons marketed along with it - chemistry which supposedly increased the ability of cells to take in oxygen. I know from experience that my own blood-oxygen saturation doesn't fall below 96%, and if that's not high enough to penetrate the membranes of the tissues which rely on oxygen for so much of their natural function, then no little pill was going to be able to make a difference (there is a condition under which the membranes become too thick, related to scleroderma, inhibiting the transport of oxygen across the barrier - and this wouldn't help that either).

In order to make a real difference, I prefer to appeal to empirically repeatable practices with as much well-founded theory behind them as possible. Boiled down to the very basic essence of the thing and then building up step-by-step thereafter until implementing the whole - or as much of that whole is truly required for the end result. I needed a small starting point and measurements of change over time.

As it turns out, candida albicans has a natural control agent already present in the body: lactobacillus acidophilus. If something disturbs the acidophilus (why candida is referred to in short by its genus, and acidophilus by its species, is beyond me) the candida is able to grow unchecked and will start in on its ambitious disruption. It so happens that 14 years ago I picked up a nasty intestinal parasite (probably amoebic) from some well water at my uncle's ranch in Colorado. The experience was not one I'd like to repeat or wish on most anyone, and I'll save you the specifics of why. This infestation, though resolved, likely was the catalyst that led to the destruction of the acidophilus and thus the "cat's away" scenario.

Bringing us now to the experiment: for the last 2 weeks I have been taking acidophilus supplements in a concentration of 4bn organisms (2 tablets with breakfast and dinner, less than $6 for 100 tablets) starting with my evening meal on Monday, January 29th. The next day, contrary to my expectations, I felt different: my peripheral tissues felt warmer, and less pained. I didn't know there was such a concentration of casual pain, but its absence suddenly shed light on the situation. Since then the affect has increased, and I've had enough presence of mind in the evenings to make real progress on my book (recently passing the 10,000 word mark - slow but steady progress, and seeing as how I still have the day job and the young kids, an impressive amount of work despite its seemingly languid pace). Everyone in the family has had the stomach flu except me, not in itself extraordinary as I'm typically resistant to these kinds of bugs, but remarkable in the amount of sleep disruption it's caused. I've been up to my elbows in buckets and bed clothes and had to spend multiple nights without the CPAP, and though tired and a little distracted the following days was able to function and have still been absent that nonspecific malaise from before. I get fatigued, but under different conditions and feeling far removed from the prior dragging near-paralysis that was for so long my constant companion.

I get hungry before I feel hypoglycemic, have been able to fast for the first time in probably a year, and no longer crave sugars (candida is also an anaerobic organism, so it was robbing the GI tract and blood of the glucose that was also my only sustenance). My next step is the introduction of coenzyme Q10 tablets to replace the depleted reserves (theorizing that the glucose is now reaching my cells, but that the aerobic processes is still inhibited), and after a week on that to begin phasing in mild exercise. The changes already have been profound.

For some reason I'm not resentful that after more than a decade of decline, such a simple remedy was available. I'm not saying that I'm done, or that this is a truly permanent magic bullet - but the improvement has been unprecedented by everything else thus far. I'll enjoy it while it lasts for what it is.